Ph.D. Thesis:

Pan, L. Monoclonal antibodies to lactate dehydrogenase and creatine kinase isoenzymes and their application in tumor immunohistology. University College London Library Publication, 1988

Articles Published in Professional Journals: 

1.      Pan, L., Diss, T.C., Cunningham, D., Isaacson, P.G. The bcl-2 gene in primary B cell lymphoma of mucosa-associated lymphoid tissue (MALT). Am. J. Pathol. 135, 7-11, 1989

2.      Pan, L.X., Beverley, P.C., Bobrow, L.G., Swallow, D.M., Isaacson, P.G. Production of monoclonal antibodies to lactate dehydrogenase (LDH) isoenzymes for immunohistochemical study on fixed tissue section. Histochem. J. 21, 638-644, 1989

3.      Wotherspoon, A.C., Pan, L.X., Diss, T.C., Isaacson, P.G. A genotypic study of low grade B-cell lymphomas, including lymphomas of mucosa associated lymphoid tissue (MALT). J. Pathol. 162, 135-140, 1990

4.      Isaacson, P.G., Wotherspoon, A.C., Diss, T., Pan, L.X. Follicular colonization in B-cell lymphoma of mucosa-associated lymphoid tissue. Am. J. Surg. Pathol. 15, 819-828, 1991

5.      Isaacson, P.G., Wotherspoon, A.C., Diss, T.C., Pan, L.X. Bcl-2 expression in lymphomas. Lancet. 337, 175-176, 1991

6.      Pan, L., Beverley, P.C., Isaacson, P.G. Lactate dehydrogenase (LDH) isoenzymes and proliferative activity of lymphoid cells--an immunocytochemical study. Clin. Exp. Immunol. 86, 240-245, 1991

7.      Pan, L.X., Xu, J.N., Isaacson, P.G. Cellular H- and M-type lactate dehydrogenase (LDH) isoenzymes and tumour diagnosis--an immunohistochemical assessment. J. Pathol. 163, 53-60, 1991

8.      Schmid, C., Pan, L., Diss, T., Isaacson, P.G. Expression of B-cell antigens by Hodgkin's and Reed-Sternberg cells. Am. J. Pathol. 139, 701-707, 1991

9.      Isaacson, P.G., Androulakis Papachristou, A., Diss, T.C., Pan, L., Wright, D.H. Follicular colonization in thyroid lymphoma. Am. J. Pathol. 141, 43-52, 1992

10.  Isaacson, P.G., Schmid, C., Pan, L., Wotherspoon, A.C., Wright, D.H. Epstein-Barr virus latent membrane protein expression by Hodgkin and Reed-Sternberg-like cells in acute infectious mononucleosis. J. Pathol. 167, 267-271, 1992

11.  Wotherspoon, A.C., Pan, L.X., Diss, T.C., Isaacson, P.G. Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue. Cancer. Genet. Cytogenet. 58, 35-38, 1992

12.  Diss, T.C., Peng, H.Z., Wotherspoon, A.C., Pan, L., Speight, P.M., Isaacson, P.G. Brief report: a single neoplastic clone in sequential biopsy specimens from a patient with primary gastric-mucosa-associated lymphoid-tissue lymphoma and Sjogren's syndrome. N. Engl. J. Med. 329, 172-175, 1993

13.  Diss, T.C., Peng, H.Z., Wotherspoon, A.C., Isaacson, P.G., Pan, L. Detection of monoclonality in low-grade B-cell lymphomas using the polymerase chain reaction is dependent on primer selection and lymphoma type. J. Pathol. 169, 291-295, 1993

14.  Pan, L., Happerfield, L.C., Bobrow, L.G., Isaacson, P.G. In situ detection of human Ig light-chain mRNA on formalin-fixed and paraffin-embedded tissue sections using digoxigenin-labelled RNA probes. Histochem. J. 25, 57-63, 1993

15.  Pan, L., Diss, T.C., Peng, H.Z., Lu, Q., Wotherspoon, A.C., Thomas, J.A., Isaacson, P.G. Epstein-Barr virus (EBV) in enteropathy-associated T-cell lymphoma (EATL). J. Pathol. 170, 137-143, 1993

16.  Wotherspoon, A.C., Doglioni, C., Diss, T.C., Pan, L., Moschini, A., de Boni, M., Isaacson, P.G. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 342, 575-577, 1993

17.  Wotherspoon, A.C., Diss, T.C., Pan, L.X., Schmid, C., Kerr-Muir, M.G., Lea, S.H., Issacson, P.G. Primary low-grade B-cell lymphoma of the conjunctiva: a mucosa-associated lymphoid tissue type lymphoma. Histopathology. 23, 417-424, 1993

18.  Diss, T.C., Pan, L.X., Peng, H.Z., Wotherspoon, A.C., Isaacson, P.G. Sources of DNA for detecting B cell monoclonality using PCR. J. Clin. Pathol. 47, 493-496, 1994

19.  Pan, L.X., Diss, T.C., Peng, H.Z., Isaacson, P.G. Clonality analysis of defined B-cell populations in archival tissue sections using microdissection and polymerase chain reaction. Histopathology. 24, 323-327, 1994

20.  Peng, H.Z., Isaacson, P.G., Diss, T.C., Pan, L.X. Multiple PCR analyses on trace amounts of DNA extracted from fresh and paraffin wax embedded tissues after random hexamer primer PCR amplification. J. Clin. Pathol. 47, 605-608, 1994

21.  Diss, T.C., Watts, M., Pan, L., Linch, D., Isaacson, P.G. The polymerase chain reaction in the demonstration of monoclonality in T cell lymphomas. J. Clin. Pathol. 48, 1045-1050, 1995

22.  Diss, T.C., Wotherspoon, A.C., Speight, P.M., Pan, L.X., Isaacson, P.G. B cell monoclonality, Epstein Barr virus and t(14;18) in myoepithelial sialadenitis and low grade B cell MALT lymphoma of the parotid gland. Am. J. Surg. Pathol. 19, 531-536, 1995

23.  Du, M.Q., Peng, H.Z., Singh, N., Isaacson, P.G., Pan, L.X. The accumulation of p53 abnormality is associated with progression of mucosa-associated lymphoid tissue lymphoma. Blood. 86(12), 4587-4593, 1995

24.  Pan, L.X., Ramani, P., Diss, T.C., Liang, J.N., Isaacson, P.G. Epstein-Barr virus associated lymphoproliferative disorder with fatal involvement of the gastrointestinal tract in an infant. J. Clin. Pathol. 48, 390-392, 1995

25.  Peng, H.Z., Du, M.Q., Ji, J.X., Isaacson, P.G., Pan, L.X. High-resolution SSCP analysis using acrylamide-agarose composite gel and a background free silver staining method. Biotechniques. 19(3), 410-413, 1995

26.  Pan, L.X., Diss, T.C., Isaacson, P.G. Invited review: The polymerase chain reaction in histopathology. Histopathology. 26, 201-217, 1995

27.  Ashton-Key, M., Singh, N., Pan, L.X., Isaacson, P.G., Smith, M.E.F. MHC antigen expression in enteropathy associated T cell lymphoma. J. Clin. Pathol. 49, 545-548, 1996

28.  Du, M.Q., Singh, N., Husseuin, A., Isaacson, P.G., Pan, L.X. Positive correlation between apoptotic and proliferative indices in gastrointestinal lymphomas of mucosa-associated lymphoid tissue (MALT). J. Pathol. 178, 379-384, 1996

29.  Du, M.Q., Diss, T.C., Xu, C.F., Peng, H.Z., Isaacson, P.G., Pan, L.X. Ongoing mutation in MALT lymphoma immunoglobulin VH gene suggests that antigen stimulation plays a role in the clonal expansion. Leukemia. 10, 1190-1197, 1996

30.  Du, M.Q., Xu, C.F., Diss, T.C., Peng, H.Z., Wotherspoon, A.C., Isaacson, P.G., Pan, L.X. Intestinal dissemination of gastric mucosa-associated lymphoid tissue lymphoma. Blood. 88, 4445-4451, 1996

31.  Nicholson, A.G., Wotherspoon, A.C., Diss, T.C., Singh, N., Butcher, D.N., Pan, L.X., Isaacson, P.G., Corrin, B. Lymphomatoid granulomatosis: evidence that some cases represent Epstein-Barr virus-associated B-cell lymphoma. Histopathology. 29, 317-324, 1996

32.  Pan, L.X., Diss, T.C., Peng, H.Z., Isaacson, P.G. Nodular lymphocyte predominance Hodgkin's disease: a monoclonal or polyclonal B-cell disorder? Blood. 87, 2428-2434, 1996

33.  Peng, H.Z., Chen, G., Du, M.Q., Singh, N., Isaacson, P.G., Pan, L.X. Replication error (RER) and p53 gene mutation in lymphomas of mucosa-associated lymphoid tissue (MALT). Am. J. Pathol. 148, 643-648, 1996

34.  Savio, A., Franzin, G., Wotherspoon, A.C., Zamboni, G., Negrini, R., Buffoli, F., Diss, T.C., Pan, L., Isaacson, P.G. Diagnosis and posttreatment follow-up of helicobacter pylori-positive gastric lymphoma of mucosa-associated lymphoid-tissue - histology, polymerase chain-reaction, or both. Blood. 87, 1255-1260, 1996

35.  Wotherspoon, A.C., Diss, T.C., Pan, L., Singh, N., Whelan, J., Isaacson, P.G. Low-grade gastric B-cell lymphoma of mucosa-associated lymphoid-tissue in immunocompromised patients. Histopathology. 28, 129-134, 1996

36.  Pan, L.X., Diss, T.C., Peng, H.Z., Isaacson, P.G. Immersion-histo polymerase chain reaction - a practical tool for visualization of single-copy genes in tissue sections. Am. J. Pathol. 150, 1245-1252, 1997

37.  Peng, H.Z., Du, M.Q., Diss, T.C., Isaacson, P.G., Pan, L.X. Clonality analysis in tumours of women by PCR amplification of X-linked genes. J. Pathol. 181, 223-227, 1997

38.  Du, M.Q., Diss, T.C., Xu, C.F., Wotherspoon, A.C., Isaacson, P.G., Pan, L.X. Ongoing immunoglobulin gene mutations in mantle cell lymphomas. Br. J. Haematol. 96, 124-131, 1997

39.  Peng, H., Du, M., Diss, T.C., Isaacson, P.G., Pan, L. Genetic evidence for a clonal link between low- and high-grade components in gastric MALT B cell lymphoma. Histopathology. 30, 425-429, 1997

40.  Du, M.Q., Peng, H.Z., Dogan, A., Diss, T.C., Liu, H., Pan, L.X., Mosley, R.P., Briskin, M.J., Chan, J.K., Isaacson, P.G. Preferential dissemination of B-cell gastric mucosa-associated lymphoid tissue (MALT) lymphoma to the splenic marginal zone. Blood 90, 4071-4077, 1997

41.  Ashton-Key, M, Diss, T.C., Pan, L, Du, M.Q., Isaacson, P.G. Molecular analysis of T-cell clonality in ulcerative jejunitis and enteropathy associated T cell lymphoma. Am. J. Pathol. 151, 493-498 1997

42.  Peng, H, Diss, T, Isaacson, P.G., Pan, L. C-myc gene abnormalities in mucosa associated lymphoid tissue (MALT) lymphomas. J. Pathol. 181, 381-386, 1997

43.  Pan, L.X., Peng, H.Z. High-resolution silver staining-based PCR-single strand conformation polymorphism (SSCP) analysis. In: Schaefer,B.C. ed., Gene cloning and analysis - current innovations, Norfolk, England, Horizon scientific press, 1997, 191-202

44.  Diss, T.C., Pan, L. Polymerase chain reaction in the assessment of lymphomas. In: Tooze,J., Franks,L.M. eds., Cancer surveys, Cold Spring Harbor Laboratory Press, 1997, 21-43

45.  Deng Z, Pan L, Ma Y: [Sequence alterations in p53 gene of hepatocellular carcinoma from high aflatoxin risk area in Guangxi]. [Chinese].  Chung-Hua Chung Liu Tsa Chih [Chinese Journal of Oncology] 19,18-21 1997

46.  Dogan A, Du MQ, Aiello A, Diss TC, Ye HT, Pan LX, Isaacson PG. Follicular lymphomas contain a clonally linked but phenotypically distinct neoplastic B-cell population in the interfollicular zone. Blood 91, 4708-4714, 1998

47.  Peng, H.Z., Isaacson, P.G., Pan, LX. Infrequent mutations of the Bax gene in B-cell lymphomas. J. Pathol. 186, 378-382 1998

48.  Peng, H, Ranaldi, R., Diss, T, Isaacson, P.G., Bearzi, I, Pan, L. High frequency of CagA+ helicobacter pylori infection in high-grade gastric MALT B-cell lymphomas. J. Pathol. 185, 409-412, 1998

49.  Peng, H.Z., Du, M.Q., Koulis, A., Aiello, A., Dogan, A., Pan, L.X., Isaacson, P.G. Non-Ig gene hypermutation in germinal centre B cells. Blood. 93 2167-2172, 1999

50.  Willis, T.G., Dalal M, Du, M.Q., Peng, H, Perry, A.R, Abdul-Rauf, M, Price, H., Karran, L., Majekodunmi, O, Wlodarska, I, Pan, L.X., Crook, T, Hamoudi, R., Isaacson, P.G., Dyer, M.J.S. Bcl 10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell. 96, 35-45, 1999

51.  Bai, X.Z., Masters, J.R., O’Donoghue, N., Kirby, R., Pan, L.X., Young, M., Stafford, M., Parkinson, M.C. Prognostic markers in clinically localized prostate cancer. Int. J. Oncol. 14, 785-791, 1999

52.  Tsang, P, Pan, L, Cesarman, E, Tepler, J, Knowles, D.M. A distinctive composite lymphoma comprised of a clonally related mantle cell lymphoma and follicle center cell lymphoma. Hum Pathol. 30, 988-992, 1999

53.  Aiello, A., Du, M.Q., Diss, T.C., Peng, H.Z., Pezzella, F., Papini, D., Giardini, R., Pilotti, S., Pan, L.X., Isaacson, P.G. Simultaneous phenotypically distinct but clonaly identical mucosa-associated lymphoid tissue and follicular lymphoma in a patient with Sjogren’s syndrome. Blood. 94, 2247-2251, 1999

54.  Diss, T.C., Pan, L.X., Du, M.Q., Parkinson, M.C., Peng, H.Z., Isaacson, P.G., Kerr, J. Parvovirus B19 is associated with benign testicular tissue as well as testicular germ cell tumours. Molecular Pathology, 52, 349-352, 1999

55.  Barnouin, K., Fredersdorf, S., Eddaoudi, A., Mittnacht, S., Pan, L.X., Du, M.Q., Lu, X. Antiproliferative function of p27kip1 is frequently inhibited in highly malignant Burkitt’s lymphoma cells. Oncogene, 18, 6388-6397, 1999

56.  Peng, H.Z., Lakhani, S.R., Lee, C.Y., Zheng, Q., Chaggar, R.K., Wright, N., Isaacson, P.G., Pan, L.X. X-linked gene transcription-based clonality analysis of defined cell populations on archival paraffin-embedded tissue sections using microdissection and RT-PCR. J. Pathol. 191, 313-317, 2000

57.  Pan, L.X., Cesarman, E., Knowles, D.M. Antigen receptor genes: structure, function, and techniques for analysis of their rearrangements. In: Knowles, D.M. eds., Neoplastic Hematopathology, Williams & Wilkins, 2000

58.  Pan, L., Peng, H. Polymerase chain reaction clonality assays based on X-linked genes. In: Killeen, A. eds., Molecular Pathology Protocols, Human Press, Chapter 8, 73-79, 2000

59.  Du, M.Q., Diss, T.C., Dogan, A., Ye H.T., Aiello A., Wotherspoon A.C., Pan, L.X., Isaacson, P.G. Clone-specific PCR reveals wide dissemination of gastric MALT lymphoma to the gastric mucosa. J. Pathol. 192, 488-493, 2000

60.  Kuhel, W.I., Gonzales, D., Hoda, S.A., Pan, L., Chiu, A., Giri, D., DeLellis, R.A. Synchronous water-clear cell double parathyroid adenoma – a hitheto uncharacterized entity? Arch. Pathol. Lab. Med. 125, 256-259, 2001

61.  Pan, L., Milligan, L., Michaeli, J., Cesarman, E., Knowles, D.M. Polymerase chain reaction (PCR) detection of kaposi’s sarcoma-associated herpesvirus (KSHV) – variations of methods, primer sets and target sequences. J Mole Diag. 3, 32-38, 2001

62.  Chiu, A., Pan, L.X., Li, Z.D., Ely, S., Chadburn, A.,Knowles, D.M. DNA polymerase Mu gene expression in B-cell non-Hodgkin’s lymphomas: an analysis utilizing in-situ hybridization. Am. J. Pathol. 161, 1349-55, 2002

63.  Li, Z.D., Pan, L, Cesarman, E, Knowles, D.M. Alterations of mRNA splicing in primary effusion lymphomas. Leuk Lymphoma. 44, 833-40, 2003

64.  Hamoudi, R., Diss, T.C., Oksenhendler, E., Pan, L., Carbone, A., Ascoli, V., Langerak, A.W., Boshoff, C., Isaacson, P., Du, M.Q. Distinct cellular origins of primary effusion lymphoma with and without EBV infection. Leukemia Research. 28, 333-38, 2004

65.  Alobeid, A., Pan, L.X., Frizzera, G. Eosinophil-rich lymphoproliferative disorder of the oral mucosa. a form of “traumatic eosinophilic granuloma”. Am J Clin Pathol. 121, 43-50, 2004