Advancing Biomedical Science through Tissue Arrays |
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Pathology
Model-Based Target Validation - The Most Effective Approach to Obtain Evidence for Clinical Relevance of a Target Purpose: Through ISH/IHC analyses on tissue or cell line sections, to obtain evidence for the speculated involvement of a RNA or protein molecule in a disease process. Help to eliminate non-disease relevant targets early and cheaply. Tissue array-based pathology model: The name is mainly referred to a tissue array that consists of tissues relevant to a process or a pathological feature of a disease or a group of pathological conditions. The tissues are purposely selected and arranged in a way that allows easy comparison, correlation and understanding of the expression patterns of the target and the disease process under investigation. Benefits: With pathology knowledge and careful ISH or IHC analysis of a target on selected pathology models, it is possible to obtain: 1. Correlative data thorough observation of: cellular localization (origin), level and normal Vs diseased cell expression pattern of a target. 2. Potential causative data through analyses: a) target expression pattern and microenvironments such as involved cells, extent, morphology alterations, et al; b) dynamic association of a target with a disease process, such as from acute to chronic, from pre-malignant to malignant, from low grade to high grade, between good response and poor response; c) relationship between the tested target and any other relevant molecules in the same disease process by analyzing these molecules in the same sections and at the same time. 3. Preclinical assessment: for antibody therapeutics safety evaluation, it is essential to know the distribution pattern of a target or existence of a cross-reactivity of a antibody therapeutics in human tissues. Example 1 of pathology model-based target validation. Example 2 of pathology model-based target validation. |
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Array-Based Pathology Models |
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| Items | Requirements | Outcome | Price |
| Test design | Basic information about the antibody and target. | Inquire | Inquire |
| Model for Inflammatory processes | To be discussed | Inquire | Inquire |
| Goblet cell hyperplasia in COPD and asthma | To be discussed | Inquire | Inquire |
| Tumor growth | To be discussed | Inquire | Inquire |
| Apoptosis related | To be discussed | Inquire | Inquire |
| Angiogenesis related | To be discussed | Inquire | Inquire |
| Invasion and metastasis | To be discussed | Inquire | Inquire |
| Tumor antigen | To be discussed | Inquire | Inquire |
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Note:
Please contact us for further information;
Example 1 of pathology model-based target validation. Example 2 of pathology model-based target validation. Orders and Inquiries Email: service@pantomics.com or info@pantomics.com Tel: 1-415-863-2380 or 1-510-207-9788 Fax:1-510-653-1227 |
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Pantomics, Inc.
457 Mariposa Street, San Francisco, CA
94107, USA.
Tel: 415-863-2380