Advancing Biomedical Science through Tissue Arrays |
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Dedicated facility |
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Positive Control Tissue List for Immunohistochemistry (IHC) Markers |
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| Markers | Positive tissue/cells |
|
AACT |
Tonsil, colon, skin |
| AAT | Tonsil, colon, liver |
| Actin, muscle | Skeletal Muscle, Tongue, Leg Muscle |
|
Actin, alpha-smooth muscle |
Myometrium; muscularis of colon |
| ACTH | Pituitary |
|
AE-1 |
Colon |
|
AE-3 |
Prostate |
| AE-1/AE-3 | Colon, Skin, Prostate, Pancreas |
| AFP | Fetal liver, Hepatoma, Fetus |
|
Albumin |
Liver |
| ALK | ALK+ anaplastic large cell lymphoma, umbilical cord |
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Androgen receptor |
Prostate |
| Aurora A/STK-15 | MCF-7 Cell, Cancer Tissue |
|
Bax |
Breast cancer |
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Bcl-2 |
Tonsil lymphoid tissue |
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Bcl-6 |
Tonsil germinal centers |
| Bcl-10 | Tonsil, appendix |
| Ber H2 | Lymphoma, Pancreas |
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BerEP4 |
Colonic epithelium; thyroid follicular epithelium |
| Beta amyloid | Alzheimer's Brain |
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Beta catenin |
Bile ducts in the liver |
| Bim | Skin/Skin Tumor |
| Bombesin | Stomach, Duodenum, Lung |
| BrdU | BrdU Treated Tissue |
| Calbindin D | Cerebellum |
| Calcitonin | Pituitary |
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Calretinin |
Neurons and nerves in colon; mesothelial lining over liver or lung, if available |
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Carcinoembryonic antigen |
Colonic mucosa |
| Casein | Lactating Mammary Gland |
| Caspase3 | Skin/Tumor, Embryo |
| Catalase | Liver, Brain (basal ganglia, thalamus, cerebellum) |
| Catenin | Intestine |
| Cathepsin D | Breast Cancer, Skin, Prostate, Liver |
| CC10 | Lung |
|
CD1a |
Thymoma (lymphoid cells) |
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CD3 |
Tonsil lymphoid tissue, appendix |
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CD4 |
Tonsil lymphoid tissue, appendix |
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CD5 |
Tonsil lymphoid tissue, appendix |
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CD8 |
Tonsil lymphoid tissue, appendix |
|
CD10 |
Tonsil germinal centers |
| CD11b | Spleen, Cerebellum (Microglia) |
|
CD13 |
Brain |
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CD15 |
Histiocytes and neutrophils in tissues, eg, colon, lung, tonsil lymphoid tissue, appendix |
| CD19 | Spleen |
|
CD20 |
Tonsil lymphoid tissue |
|
CD21 |
Tonsil germinal centers |
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CD23 |
Tonsil germinal centers |
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CD25 |
Tonsil lymphoid tissue |
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CD30 |
Isolated lymphoid cells around germinal centers in tonsil |
|
CD31 |
Blood vessels in various tissues |
|
CD34 |
Blood vessels in various tissues |
|
CD35 |
Tonsil germinal centers |
| CD38 | Spleen |
| CD40 | Spleen |
| CD41 | Spleen |
|
CD43 |
Tonsil lymphoid tissue |
| CD44 | Spleen, thymus |
|
CD45RO |
Tonsil lymphoid tissue |
|
CD45RB, leukocyte common antigen |
Tonsil lymphoid tissue, appendix |
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CD54 |
Liver, lung |
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CD56 |
Brain tissue |
|
CD57 (Leu7) |
Isolated cells in germinal centers in tonsil; prostatic acini |
|
CD68 |
Histiocytes in tissues, eg, colon, lung |
|
CD79a |
Tonsil lymphoid tissue |
| CD80 | Spleen |
|
CD99a (MIC2) |
Thymoma (lymphoid cells) |
| CD105 | Kidney |
|
CD117 (c-kit) |
Mast cells in various tissues, eg, myometrium, colon |
|
Cdc2 |
Breast cancer |
|
Cdk2 |
Colon |
| Cdk4 | Skin |
|
c-erbB2 |
Breast cancer |
| Choriogonadotrophin | Placenta |
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Chromogranin-A |
Isolated endocrine cells in crypts of colonic mucosa |
| CKR6 | Lymph node |
| CKR7 | Lymph node |
| CNPase | Brain/Glia Tumor |
|
Collagen I |
Placenta |
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Collagen IV |
Placenta, tonsil |
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Cox2 |
Colon, appendix |
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CX3CR1 |
Appendix, lymph node, tonsil |
| CXCR4 | Skin |
|
Cyclin D1 |
Suprabasal cells in stratified squamous epithelium of tonsi |
|
CYP1B1 |
Liver |
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Cytokeratin 7 |
Various epithelial structures, except colon |
| Cytokeratin 8&18 | Skin, Pancreas/Tumor |
| Cytokeratin 14 | Skin |
| Cytokeratin 15 | Skin |
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Cytokeratin 20 |
Colonic epithelium, pancreas |
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Cytokeratin - high molecular weight |
Stratified squamous epithelium of tonsil; basal cells of prostate |
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Cytokeratin - low molecular weight |
Any of the epithelial structures, except the stratified squamous epithelium of tonsil |
|
Cytokeratin-Pan |
Any of the epithelial structures, eg, breast cancer, lung, tnymoma, colon, prostate, thyroid |
| DBA44 | Spleen |
| Defensin1-alpha (HDEFA1) | Skin |
| Defensin1-beta (NBD-1) | Skin |
| Defensin2-beta (HBD-2) | Skin |
|
Desmin |
Myometrium; muscularis of colon |
| Dopamine Hydroxylase | Brain (Striatum/Substantia Nigra) |
| E-Cadherin | Mammary Epithelium |
|
E-GFR |
Placenta |
|
Epithelial membrane antigen (EMA) |
Some of the epithelial structures |
| Eastrogen | Normal beast/breast cancer |
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Estrogen receptor |
Myometrium, breast, uterus, prostate |
| F4/80 | Spleen, Thymus, Lung, Liver |
|
Factor Vlll-related antigen |
Blood vessels in various tissues |
| FAS | Spleen, Thymus, Colon |
| Fas-L | Spleen, Thymus, Colon |
| Flag (M2) | Heart Muscle |
| Fhit | Muscle |
| Flk-1 | Colon Carcinoma, Blood Vessel Endothelium |
| Filaggrin | Skin |
| FSH | Pituitary |
|
GAPDH (V-18) |
Liver, lung |
| Gastrin | Stomach (Pyloric Mucosa) |
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GCDFP-15(BRST-2) |
Breast cancer |
| GFAP | Brain (Striatum, Cerebellum) |
|
Glial fibrillary acidic protein |
Brain tissue |
| Glucagon | Pancreas |
| Glycophorine A | Bone Marrow |
| GRB2 | Colon carcinoma |
| Growth hormone | Pituitary |
| GSH2 (E-20) | Lens |
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HBcAg |
Hepatocytes (Cirrhosis associated with hepatitis B) |
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HBsAg |
Hepatocytes (Cirrhosis associated with hepatitis B) |
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hCG |
Placenta |
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HDJ2 |
Tonsil |
| Helicobacter Pylori | Helicobacter infected gastric mucosa or folicular gastritis |
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Heme-oxygenase-1 (HO-1) |
Lung |
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HEP-PAR 1 |
Hepatocytes |
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HGF |
Liver |
| HIF-1 alpha | Prostate Tumor, Lung Tumor |
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Histone H2AX |
Tonsil |
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Histone H3 (Phospho-Histone H3) |
Tonsil, appendix, Skin, Spleen, Small Intestine |
| HMB-45 | Melanoma |
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HPL |
Placenta, tonsil, colon |
|
HSA (hepatocyte specific antigen) |
Liver |
| HSP70 | Skin, Pulmonary Arteries, Smooth Muscle |
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IgA |
Tonsil lymphoid tissue, appendix |
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IgD |
Tonsil lymphoid tissue, appendix |
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IgE |
Tonsil lymphoid tissue, appendix |
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IgG |
Tonsil lymphoid tissue, appendix |
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IgM |
Tonsil lymphoid tissue, appendix |
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Ig Kappa light chain |
Tonsil lymphoid tissue, appendix |
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Ig lambda light chain |
Tonsil lymphoid tissue, appendix |
|
IL-1 |
Lung, appendix |
|
IL-6 |
Lung, appendix |
|
IL-8 |
Lung, appendix |
| Insulin | Pancreas |
| Insulin A | Pancreas |
| Integrin | Skin (Basement Membrane) |
| Involucin | Skin |
|
Ki67 |
Many different tissues, eg, lymphoid tissue in tonsil |
|
KP-1 |
Colon, liver |
| Laminin | Skin, Kidney |
| LAT | Spleen |
|
Leukocyte common antigen (CD45RB) |
Tonsil lymphoid tissue |
| Ly-6A/E | Thymus |
| Ly-6G | Spleen |
| Ly-49 | Spleen |
|
MAC |
Placenta |
|
MAP2 |
Brain |
| Mast Cell Tryptase | Bone Marrow, Lung, Skin, Colon |
| MEK 1/2 (phospho-MEK 1/2) | Breast Cancer |
| Melan-A (MART-1) | Melanoma |
| MHV | MHV Liver |
| MIP2 | Skin |
| Mitf | Bone Marrow, Lung, Skin, Colon |
|
MMP-2 |
Placenta |
|
MMP-9 |
Lung |
| MOMA1 | Spleen |
| MRP14 | CAPAN-1 Cells, Lung Cancer |
|
MT-1 |
Tonsil, appendix |
|
MT-2 |
Tonsil, appendix |
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Myeloperoxidase |
Neutrophils within appendicytis and the blood vessels of various tissues |
| Myogenin | Fetal muscle, rhabdomyosarcoma |
| MyoD1 | Fetal muscle, rhabdomyosarcoma |
| Myosin | Skeletal Muscle, Tonsil, Tongue |
| Myoglobin | Heart, Tonsil |
|
Nestin |
Brain |
|
NeuN |
Brain |
|
Neurofilament |
Brain tissue |
|
Neutrophil esterase |
Tonsil, appendix |
|
Nitrotyrosine |
Placenta |
|
NOS2 |
Liver |
|
NOS3 |
Brain |
|
NSE (neuron specific enolase) |
Brain |
|
Occludin |
Lung |
| Osteonectin/Sparc | Cartilage, Lens |
|
P53 |
Thymoma (isolated cells with weak staining); tonsil lymphoid tissue (isolated cells with weak staining) |
|
P63 |
Breast cancer, colon |
| Pancreatic Polypeptide | Pancreas, Duodenum, Gastric Antrum |
| Panendothelial Cell Antigen | Kidney, Spleen, Lung |
| Pap 2b | Bladder |
| Parathyroid hormone | Parathyroid adenoma |
| PAR, alpha | Ischemia Brain (Piriform Cortex) |
| Pax-5 | Spleen |
|
Paxillin |
Placenta |
|
PCNA |
Tonsil, appendix |
| PDGF Receptor | Mammary Carcinoma |
| PEP-1 | Malignant Melanoma, Amelanotic |
| PEP-13 | Malignant Melanoma, Amelanotic |
|
PLAP |
Placenta, tonsil |
|
Progesterone receptor |
Myometrium, Normal Breast/Breast Cancer |
| Prolactin | Pituitary |
|
Prostatic specific antigen |
Prostate |
| PS2 | Breast Cancer |
| Sarcomeric Actin | Tongue, Tonsil |
|
S100 protein |
Brain tissue |
|
SCF (stem cell factor) |
Brain |
|
Serotonin |
Appendix, lung |
| SLUG | Tongue |
| SMAD2 (phospho-SMAD2) | Embryo |
|
Somatostatin |
Pancreas, Brain |
|
Somatostatin receptors |
Pancreas, Brain |
|
Sos-1 |
Placenta |
| SOX-10 | Embryo |
|
Surfactant |
Lung (pneumocytes) |
| Survivin Ab-3 | mach/Lung Tumor |
| SV40 | Tumor, Mammary Carcinoma |
|
Synaptophysin |
Brain tissue; isolated endocrine cells in crypts of colonic mucosa |
| Tau | Alzheimer's Brain |
|
TCR, beta |
Thymoma, tonsil, appendix |
| Testosterone | Testis |
|
TGF-beta RI |
Prostate |
|
TGF-beta1 LC |
Placenta |
|
TdT |
Thymoma (lymphoid cells) |
| TH (Tyrosine Hydroxylase) | Brain (Striatum, Substantia Nigra) |
| Thymine Dimer | Skin (UV Damage) |
|
Thyroglobulin |
Thyroid |
|
Thyroid transcription factor-1 (TTF-1) |
Lung (pneumocytes); thyroid |
| TLT-1 | Spleen |
|
TNF, alpha |
Lung, skin |
| TRAP (Tartrate resistant acid phosphatase) | Alveolar macrophages, osteoclasts, spleen and liver, hairy cell leukemia |
| Tubulin III, beta (Tuj1) | Brain (Cerebral Cortex) |
| Ubiquitin | Alzheimer's/Parkinson's Brain |
| UCP-1 | Pancreas |
| UCP-2 | Pancreas |
|
ULEX |
Prostate, tonsil |
|
VCAM-1 |
Vessels in Tissue |
| VE-Cadherin | Kidney |
| VEGF | Pancreas, Kidney, Adenocarcinoma |
| VEGF R1 | Skin, Brain, Hey Cells, Angiosarcoma |
| VEGF R2 (Flk-1) | Kidney, Heart, Prostate Carcinoma, Tumor |
|
Vimentin |
Colon, Prostate, Tonsil, uterus, Ureter |
| VIP (Vaso Intestinal Polypeptide) | Gastric Antrum, Small Intestine, Brain (Amygdala) |
|
vWF (von Willebrand Factor) |
Tonsil |
| WT-1 (Wilms' Tumor) | Kidney (Glomeruli), Testis |
| 8-OHdG | Skin |
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