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CD3 Rabbit Monoclonal Antibody

CD3 Rabbit Monoclonal Antibody

$250.00Price
CD3's immunohistochemical detection locates the cytoplasmic component of CD3 protein. Anti-CD3 is considered to be a pan-T-cell marker and reacts with an antigen present at the surface and in the cytoplasm of T lymphocytes. Anti-CD3 is widely used for the identification of immature and mature T-cell malignancies.1-8

  • Intended Use

    For research use only. For IHC use on formalin-fixed, paraffin-embedded tissue sections.

  • Targets

    CD3

  • Cell Localization

    Membrane & cytoplasmic

  • Marker For

    Pan-T- cells and T-cell malignancies

  • Pathology Field

    Hematopathology

  • Control Tissues

    tonsil, CD3IHC-TMA

  • References

    1. Denning SM, et al. Activation of human thymocytes via CD3 and CD2 molecules. In: McMichael AJ, et al. eds. Leucocyte Typing III, White Cell Differentiation Antigens. Oxford-New York-Tokyo. Oxford University Press. 1987; 144-7.
    2. Beverley PC, et al. Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody. Eur J Immunol. 1981; 11:329-34.
    3. Clevers H, et al. The transmembrane orientation of the epsilon chain of the TcR/CD3 complex. Eur J Immunol. 1988; 18:705-10.
    4. Campana D, et al. The cytoplasmic expression of CD3 antigens in normal and malignant cells of the T lymphoid lineage. J Immunol. 1987; 138:648-55.
    5. Hedvat CV, et al. Application of tissue microarray technology to the study of non-Hodgkin's and Hodgkin's lymphoma. Hum Pathol. 2002; 33:968-74.
    6. Karube K, et al. Non-B, non-T neoplasms with lymphoblast morphology: further clarification and classification. Am J Surg Pathol. 2003; 27:1366-74.
    7. Dogan A, et al. Micronodular T-cell/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosis. Am J Surg Pathol. 2003; 27:903-11.
    8. Axdorph U, et al. T-cell-rich B-cell lymphoma - diagnostic and therapeutic aspects. APMIS. 2002; 110:379-90.

  • **

    We also provide CD3 antibody for IHC staining at $30 - $50 per slide (more information).

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