ALK Rabbit Monoclonal Antibody
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase of the insulin receptor superfamily. ALK is typically expressed at low levels in regions of the developing central and peripheral nervous system. ALK may be activated in cancer through multiple mechanisms. The most common mechanism is through formation of a fusion protein from chromosomal translocations, as in the case of anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumors. ALK may also be amplified through mutation, as in neuroblastomas. Various solid tumors, such as non-small cell lung carcinoma (NSCLC) and brain cancers were also found to aberrantly express ALK. ALK staining is present within both the nucleus and cytoplasm, and are positive in about 60% of ALCL. ALK protein expression by tumor cells is an independent prognostic factor that predicts a favorable outcome.
Intended Use
For research use only. For IHC use on formalin-fixed, paraffin-embedded tissue sections.Targets
ALKCell Localization
Cytoplasmic & nuclearMarker For
ALK+ anaplastic large cell lymphomaPathology Field
HematopathologyControl Tissues
ALK+ ALCL lymphoma, ALKIHC-TMAReferences
1. Morena D et al. Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes. Elife 5:N/A (2016). Read more (PubMed: 26987019) ยป
2. Colomba A et al. Inhibition of Rac controls NPM-ALK-dependent lymphoma development and dissemination. Blood Cancer J 1:e21 (2011). Read more (PubMed: 22829165)**
We also provide ALK antibody for IHC staining at $30 - $50 per slide (more information).